Greenhills in the sixties was neither hilly nor green but the developers thought "Greenhills"was an attractive name so it was. In 1961, the Ortigas Company donated 5,030 sqm lot for the construction of the church provided that it is semi-concrete and construction for the church will start a year from date of donation and be completed within three years.

However, Rufino Cardinal Santos, archbishop of Manila, had difficulty in the past to permit building a church in the subdivision since 2.4 kilometers from the site there is the parish of St. Francis of Assisi of the Capuchins. The Oblates intended to accept the donation and erect there a sanctuary and a seminary. In December 16, 1961, Fr. Guido Coletti, OSJ, in behalf of the Oblates, sent a letter to Cardinal Santos requesting permission to establish a Community House in the Archdiocese to facilitate the continuation of the studies of the seminarians studying in San Jose Seminary. As soon as the Cardinal granted his permission the Company approved the donation of the site in Greenhills. The Mañosa family who are friends of Fr. Visintainer offered their help in conceiving the architectural design of the project.

The condition asked by the company was not immediately met due to financial constraints. For thirty months, five times a week and dressed in black sotana, Fr. Guido, all the way from Batangas where he was assigned that time, kept coming to Manila to solicit contributions. Eventually, he raised enough fund to begin the construction.

When the church was copletely built together with the seminary and rectory behind it, the new temple of God was blessed on April 12, 1966. But even before it was finished the first Misa de Gallo was already celebrated on December 16, 1965 with the La Salle Brothers singing during the Mass. What is now the mortuary used to be the chapel of Our Lady of Mt. Carmel where daily masses were celebrated although the Sunday Eucharist is celebrated inside the uncompleted Church. In March, 1967 it became a parish with the initial 3,500 parishioners, some coming from Wack-wack Village, White Plains and areas near Camp Crame. Fr. Guido was appointed as the first parish priest.

Being alone at the beginning, several priests came to help him. They were the late famous Jose delos Santos from La Vista, Quezon City and Fr. Federico Lano, OSJ. With more parishioners coming in he had to get the assistance of the newly ordained priests like Fr. Alfredo Piad, OSJ, Fr. Constantino Conti, OSJ, Fr. Ray dela Cruz, OSJ, Fr. Ed Bayani, OSJ, Fr. Celso Alcantara, OSJ, Fr. Pacifico Ortiz, SJ and Fr. Francis Siguan, OSJ.

In order to give time for Fr. Guido to concentrate on his new projects, Fr. Conti was assigned to replace him as Parish Priest in June 1989. Fr. Conti served as its pastor until 1996. After being the provincial superior of the Philippine Province, Rev. Fr. Napoleon Jinon, OSJ was appointed as the third parish priest. After eight years, in 2004, Rev. Fr. Venancio Silva, OSJ succeeded him. In May 2007, Fr. Noel B. Magtaas became the fifth parish priest. Three years after, in 2010, Rev. Fr. Maximo Sevilla, Jr. was appointed as the new parish priest. At present, the parish is spearheaded by Rev. Fr. Aleixius Magtibay, OSJ who was appointed last 2013.

Fr. Guido's dream for the Province has been realized. Today, the parish serves Northeast Greenhills, Greenhills East, North Greenhills and the chapels of Greenhills Shopping Center (Holy Family Chapel) and of Brgy. West Crame, San Juan City (Sacred Heart Chapel and Immaculate Conception Chapel). It is also included among the top ten wedding Churches in Metro Manila.