In 1978, the late Rev. Fr. Guido Coletti , OSJ received a relatively vast lot, donated by a parishioner from Greenhills, Mandaluyong, the late Don Antonio Zuarregui, Sr. It was located along the slope of a hill near Marcos Highway, Antipolo, Rizal.

At first, there were some apprehensions in establishing it as a parish due to a relatively thin population around the perimeter of the church. But Fr. Guido saw its potential. The parish was named St. Anthony of Padua. The Archdiocese of Manila designated it as a quasi-parish. At the back of the Church, the OSJ Novitiate House was also established (until today the church is still known as "Seminaryo").

The OSJ priests assigned even reached as far as Boso-boso to the east and Masinag to the west. Literally speaking, there are five parishes that were erected within this area of ministry: St. John Marie Vianney Parish (Brgy. Mambungan), Sto. Niño de Praga Parish(Brgy. Bagong Nayon), Diocesan Shrine and Parish of St. Therese of the Child Jesus (Masinag), Nuestra Señora de la Anunciata Parish (Boso-boso), and Blessed Lodovico Pavoni Parish (Brgy. Mambugan).

Due to some legalities with the donation of the lot, the church was only recognized and consecrated as a Parish in 2003 by the Diocese of Antipolo. Rev. Fr. Delbert Jardinaso, OSJ was its first installed parish priest.

At present, it serves in the following barangays and villages: Brgy. Langhaya, Brgy. Inarawan, Forest Hills, Brgy. Cabading, Brgy. Puting Bato and Bagong Nayon II.