On March 19, 1949, the Parish of the Holy Family was initiated by the late Rev. Fr. Egidio Mortera, OSJ in Brgy. Alupay, Rosario, Batangas. It was seperated from Nuestra Señora del Rosario Parish of the main town. It was officially inaugurated in December 1949 by the bishop of Lipa, Msgr. Alfredo Verzosa, DD. Fr. Egidio was installed as its first pastor.

The parish is comprised of the following barangays and sitios: Alupay, Antipolo, Balibago, Calantas, Mabato, Mabunga, Macalamcam A, Macalamcam B, Maligaya, Matamis, Natu, Nasi, Palakpak, Pinagsibaan, Puting Kahoy, Salao, San Isidro and Tulos. The first church was made of wood and roofs of galvanized iron sheets. In 1967, through the initiative of Rev. Fr. Guido Coletti, OSJ, the old and decaying church was replaced with a newer one made of concrete.

With the installation of a new retablo in 2000, the church became one of most sought wedding churches in Batangas.